Lupus & antiphospholipid syndrome
Long-term renal outcomes, cardiovascular events and severe infections in patients with lupus nephritis: MassiLUP cohort 2001–2022
Authors' conclusion
Despite free access to treatment and care in France, the long-term prognosis of patients with LN remains burdened both by the risk of CKD, and the risks of cardiovascular and infectious events.
Study context
- Population
- Patients with a first flare of biopsy-proven LN, 2001–2022, University Hospital of Marseille, France (MassiLUP)82.7% female
- Participants
- 168 patients
- Outcome
- Survival without CKD (stages 3, 4 and 5)
- Follow-up
- 5 and 10 years
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Survival without CKD
Survival without chronic kidney disease (CKD) at 5 years
82.9%
Survival without CKD at 10 years
74.6%
Patients who developed CKD
41
24.4%
Patients who reached ESKD
19
11.3%
Observational data: associations, not effects.
Further findings
Survival without cardiovascular event · 5 and 10 years
- Patients with a cardiovascular event
- 34 (20.2%)
- At 5 years
- 85.7%
- At 10 years
- 77.3%
Survival without severe infection (hospitalization or zoster) · 5 and 10 years
- Patients with a severe infection
- 59 (35.1%)
- At 5 years
- 76.3%
- At 10 years
- 63.8%
Survival without cancer · 5 and 10 years
- Patients with a cancer
- 12 (7.1%)
- At 5 years
- 96.3%
- At 10 years
- 92.9%
Deaths
- Patients who died (three severe infections and one stroke)
- 4
Original publication
Long-term renal outcomes, cardiovascular events and severe infections in patients with lupus nephritis: MassiLUP cohort 2001–2022. Rheumatology (Oxford). Published 13 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →