Long-term outcomes of JIA-associated uveitis: a systematic review and meta-analysis
Authors' conclusion
Long-term prevalence and cumulative incidence of JIAU complications may persist in adulthood, with >10% developing severe visual impairment despite biologic therapy.
Study context
- Population
- JIA-associated uveitis with ≥5 years of follow-up and/or young people ≥18 years old, studies published after 2000
- Participants
- 2,208 participants22 studies
- Outcome
- Long-term ocular damage (cumulative incidence of complications)
Methodological detailsNewcastle-Ottawa Scale quality assessment, sensitivity and reporting bias analyses
- Newcastle-Ottawa Scale quality assessment
- Sensitivity and reporting bias analyses
Pooled result
As reported in the abstract
Pooled incidence of complications
Severe visual impairment, pooled incidence (95% CI 9.9% to 22.6%), at ≈18 years
16.6%
Cataract, most frequent complication, pooled estimates (PE)
44.3%
95% CI 27.5% to 61.7%
Original publication
Long-term outcomes of JIA-associated uveitis: a systematic review and meta-analysis. RMD Open. Published 27 November 2025. doi:10.
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