Long-term follow-up of children with chronic non-bacterial osteomyelitis—assessment of disease activity, risk factors, and outcome
Authors' conclusion
An improvement of physician global disease activity (PGDA), patient reported overall well-being and imaging-defined disease activity measures was documented, suggesting that inactivity of CNO disease can be reached.
Study context
- Population
- Children and adolescents with confirmed CNO registered in the National Pediatric Rheumatologic Database (NPRD) during their first year of disease, 2015–202181 analysed at 4 years
- Participants
- 400 children
- Outcome
- Clinical and MRI lesions per patient, inclusion vs 4-year follow-up
- Follow-up
- Up to 4 years
Methodological detailsNational Pediatric Rheumatologic Database (NPRD), follow-up up to 4 years
- National Pediatric Rheumatologic Database (NPRD)
- Follow-up up to 4 years
Main finding
As reported in the abstract
up to 4 years
Mean clinical lesions at inclusion
2.0
Mean MRI lesions at inclusion
3.0
Mean clinical lesions at 4 years (p < 0.001)
0.5
Mean MRI lesions at 4 years (p < 0.001)
0.9
Observational data: associations, not effects.
Further findings
Severe disease course (physician global disease activity (PGDA) > = 4)
- Patients with severe disease course
- 5-7%
- Predictors: site of inflammation (pelvis, lower extremity, clavicle), increased ESR, multifocal disease at first documentation
PedCNO70 · 4YFU
- Patients reaching PedCNO70
- 55%
Treatment
- Increase of DMARDs over the years; bisphosphonates rather considered in the first years of disease
Original publication
Long-term follow-up of children with chronic non-bacterial osteomyelitis—assessment of disease activity, risk factors, and outcome. Arthritis Res Ther. Published 28 November 2023. doi:10.
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