L-shaped association between serum 25-hydroxyvitamin D and all-cause mortality of individuals with rheumatoid arthritis
Main finding · All-cause mortalityResult — go to the resultHazard ratio 0.95 CI 0.92–0.98Authors' conclusion
An L-shaped association between serum 25-hydroxyvitamin D and all-cause mortality was found among patients with RA
Study context
- Population
- Patients with RA from National Health and Nutrition Examination Survey (NHANES) 2001–14 (mean age 59.89 years; 58.94% female)
- Participants
- 1,466 patients10,453 person-years
- Exposure
- Higher vs lower serum 25-hydroxyvitamin D
- Outcome
- All-cause mortality (National Death Index death certificate records)
Methodological detailsNHANES 2001-14, Cox proportional hazards models, generalized additive model, smooth curve fitting, 2-piecewise Cox proportional hazards models
- NHANES 2001-14
- Cox proportional hazards models
- Generalized additive model, smooth curve fitting
- 2-piecewise Cox proportional hazards models
Main finding
All-cause mortality
Hazard ratio
0.95
CI 0.92–0.98
P < 0.01
Higher 25-hydroxyvitamin Dvs <25.00 nmol/l
HR 0.95 (CI 0.92–0.98); P < 0.01
As reported in the abstract
- All-cause deaths
- 268
Observational data: associations, not effects.
Further findings
Cause-specific deaths
- CVD deaths
- 52
- Cancer deaths
- 48
Serum 25-hydroxyvitamin D level
- Weighted mean 25-hydroxyvitamin D (SD), nmol/l
- 59.26 (24.99)
- Deficient or severe deficient vitamin D (<50.00 nmol/l)
- 38.95%
Original publication
L-shaped association between serum 25-hydroxyvitamin D and all-cause mortality of individuals with rheumatoid arthritis. Rheumatology (Oxford). Published 11 June 2022. doi:10.
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