Krill Oil for Knee Osteoarthritis: A Randomized Clinical Trial
An erratum to this article was published (JAMA, 26 Sep 2024 ↗)
Primary result · Knee pain VAS, mean changeResult — go to the resultMean difference −0.3 95% CI −6.9 to 6.4Authors' conclusion
Among people with knee osteoarthritis who have significant knee pain and effusion-synovitis on magnetic resonance imaging, 2 g/d of daily krill oil supplementation did not improve knee pain over 24 weeks compared with placebo.
Study context
- Population
- People with clinical knee OA, significant knee pain and effusion-synovitis on MRI, 5 Australian cities222 (85%) completed
- Participants
- 262 people
- Comparison
- Krill oil 2 g/d vs matching placebo for 24 weeks
- Krill oiln = 130
- Placebon = 132reference
- Primary endpoint
- Change in knee pain by VAS (0-100; 0 least pain; minimum clinically important improvement = 15)
- Follow-up
- 24 weeks
Methodological detailsmulticentre, double-blind, placebo-controlled
- Multicentre
- Double-blind
- Placebo-controlled
Primary result
Knee pain VAS, mean change
Mean difference
−0.3
95% CI −6.9 to 6.4
Change by group
Krill oil
−19.9
mean
Placebo
−20.2
mean
Placebovs Krill oil
mean difference −0.3 (95% CI −6.9 to 6.4)
As reported in the abstract
Safety
One or more adverse events
Events
| Outcome | Krill oil | Placebo |
|---|---|---|
| Musculoskeletal and connective tissue disorders (most common AEs), occurrencesOccurrences (times), not patients | 32 | 42 |
| Knee pain (AE) | 10 | 9 |
| Lower extremity pain (AE) | 1 | 5 |
| Hip pain (AE) | 3 | 2 |
Original publication
Krill Oil for Knee Osteoarthritis: A Randomized Clinical Trial. JAMA. Published 18 June 2024. doi:10.
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