Lupus & antiphospholipid syndrome
Kidney Hematopoietic Stem and Progenitor Cells Contribute to Myeloid Development and Pathology in Lupus Nephritis
Authors' conclusion
EMH occurs in the kidneys during LN and contributes to disease progression through local myeloid cell expansion.
Study context
- Population
- Two murine lupus nephritis (LN) models (MRL/lpr and TLR7 agonist induced); urine samples from patients with LN
Methodological detailstwo murine LN models (MRL/lpr and TLR7 agonist induced), single-cell RNA sequencing, adoptive transfer experiments, human urine samples
- Two murine LN models (MRL/lpr and TLR7 agonist induced)
- Single-cell RNA sequencing
- Adoptive transfer experiments
- Human urine samples
Main finding
As reported in the abstract
- Kidney Lin-CD45+Sca1+ cells enriched in mice with LN and correlated with increased proteinuria, elevated blood urea nitrogen and kidney histologic severity
- These cells showed myeloid differentiation potential and shared transcriptional features with bone marrow (BM) progenitors
- Trajectory analysis: BM-derived progenitors migrate to the kidneys and undergo local maturation
- Adoptive transfer of LN-derived BM hematopoietic stem and progenitor cells (HSPCs) induced kidney damage and myeloid infiltration, particularly under TLR7 stimulation
- Kidney Sca1+ cells expressed CD44 and localized near hyaluronan (HA)-producing stromal cells in the renal pelvis
- Human LN: urinary progenitor cells correlated with kidney dysfunction and HA levels
Original publication
Kidney Hematopoietic Stem and Progenitor Cells Contribute to Myeloid Development and Pathology in Lupus Nephritis. Arthritis Rheumatol. Published 28 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →