Integrated analysis of dermatomyositis reveals heterogeneous immune infiltration and interstitial lung disease-associated endotype
An erratum to this article was published (Arthritis Res Ther, 26 May 2026 ↗)
Authors' conclusion
Our data suggest that serum CXCL10 and CXCL11 reflect the inflammatory burden of DM.
Study context
- Population
- Patients with dermatomyositis (DM), with or without ILD, and healthy controls
- Participants
- 32 / 16 / 19
- Comparison
- DM vs DM-ILD vs healthy controls
- DMn = 32
- DM-ILDn = 16
- Healthy controlsn = 19reference
Methodological detailsOlink proteomic analysis, skin transcriptomic analysis, follow-up validation, immunofluorescence
- Olink proteomic analysis
- Skin transcriptomic analysis
- Follow-up validation
- Immunofluorescence
Main finding
As reported in the abstract
- Serum proteomics showed an inflammatory signature of DM; GO and KEGG enrichment identified chemotaxis-related pathways
- Skin transcriptomics: upregulated inflammatory responses and M1 macrophage infiltration in DM
- CXCL10 and CXCL11 highly associated with immune infiltration and DM progression
Original publication
Integrated analysis of dermatomyositis reveals heterogeneous immune infiltration and interstitial lung disease-associated endotype. Arthritis Res Ther. Published 8 February 2025. doi:10.
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