Lupus & antiphospholipid syndrome
Informing trial measurement in systemic lupus erythematosus: frequency of domain-specific disease activity in a multinational cohort
Authors' conclusion
Serological, renal, cutaneous, musculoskeletal and haematological manifestations predominate in patients with active SLE; other organs are affected infrequently.
Study context
- Population
- Multinational longitudinal SLE cohort, prospectively collected 2013–2020 (92.0% female, 88.9% Asian)
- Participants
- 42,345 visits
- Exposure
- SLEDAI-2K ≥6 vs SLEDAI-2K <6
- SLEDAI-2K ≥6n = 10,031
- SLEDAI-2K <6n = 32,314
- Outcome
- Prevalence of disease activity in individual SLE organ domains (SLEDAI-2K, nine organ systems)
Methodological detailsmultinational, longitudinal
- Multinational
- Longitudinal
Main finding
As reported in the abstract
Organ-specific disease activity at least once during follow-up (per patient)
- Serological
- 75.5%
- Renal
- 41.6%
- Cutaneous
- 36.5%
- Musculoskeletal
- 20.1%
- Haematological
- 19.1%
- Serositis
- 3.4%
- Vasculitis
- 3.4%
- CNS activity
- 3.0%
- Fever
- 2.9%
Observational data: associations, not effects.
Further findings
Most common active manifestations in visits with SLEDAI-2K ≥6
- Serological
- 89.8%
- Renal
- 72.9%
- Cutaneous
- 26.4%
- Musculoskeletal
- 14.3%
Disease activity still present in visits with SLEDAI-2K <6
- Renal
- 7.3%
- Cutaneous
- 6.7%
- Haematological
- 5.8%
- Musculoskeletal
- 1.3%
Original publication
Informing trial measurement in systemic lupus erythematosus: frequency of domain-specific disease activity in a multinational cohort. Lupus Sci Med. Published 8 July 2025. doi:10.
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