Spondyloarthritis & psoriatic arthritis
Inflammation, bone loss and 2-year bone formation at the same vertebra in axial spondyloarthritis: a multilevel MRI and low-dose CT analysis
Authors' conclusion
In r-axSpA, while vertebral inflammation was associated with lower vertebral TBD, lower vertebral TBD itself did not increase the risk for new bone formation at the same vertebra.
Study context
- Population
- Patients with radiographic axial spondyloarthritis (r-axSpA) in the multicentre 2-year Sensitive Imaging in Ankylosing Spondylitis cohort; whole spine (C3-L5)
- Participants
- 50 patients
- Exposure
- Vertebrae with vs without MRI-BME (trabecular bone density (TBD)); TBD and 2-year syndesmophyte formation or growth
- Outcome
- Association of inflammation (MRI-BME) with lower TBD (HU on low-dose CT (ldCT)), and of lower TBD with 2-year syndesmophyte formation or growth at the same vertebra
- Follow-up
- 2 years
Methodological detailsmulticentre, multilevel generalised estimating equations, vertebra as unit of analysis
- Multicentre
- Multilevel generalised estimating equations
- Vertebra as unit of analysis
Main finding
As reported in the abstract
Inflammation and TBD; TBD and 2-year syndesmophyte formation or growth
Confounder-adjusted association of inflammation with lower TBD, regression coefficient
−51
95% CI −63 to −39
Observational data: associations, not effects.
Further findings
Prevalence at baseline and 2-year progression (vertebrae)
- Baseline MRI-BME, vertebrae 300/985
- 30%
- Syndesmophytes, vertebrae 588/910
- 65%
- Syndesmophyte formation or growth, at-risk vertebrae 124/691
- 18%
- TBD Hounsfield units (HU) decreased from cranial to caudal vertebrae
- BME and syndesmophytes most prevalent at thoracolumbar region
Original publication
Inflammation, bone loss and 2-year bone formation at the same vertebra in axial spondyloarthritis: a multilevel MRI and low-dose CT analysis. RMD Open. Published 9 February 2023. doi:10.
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