Spondyloarthritis & psoriatic arthritis
Impact of NSAIDs on 8-year cumulative incidence of major cardiovascular events in patients with ankylosing spondylitis: a nationwide study
Authors' conclusion
MACE incidence rates at 8 years are low in patients newly benefiting from LTI for AS.
Study context
- Population
- French patients newly receiving Long-term Illness benefits for AS, 2010–2013; follow-up to 31 December 2018 (mean age 43.0 years, 44.9% male)
- Participants
- 22,929 patients
- Exposure
- Exposure to NSAIDs, anti-TNF and anti-IL17 vs no exposure, for MACE risk
- Outcome
- Cumulative incidence of MACE:
- Stroke
- MI
- Follow-up
- 8 years
Methodological detailsmedico-administrative database (SNDS), competing risk analysis, propensity score and inverse weighting
- Medico-administrative database (SNDS)
- Competing risk analysis
- Propensity score and inverse weighting
Main finding
As reported in the abstract
8-year cumulative incidence
MACE
1.81%
1.61–2.05
Stroke
0.97%
0.83–1.14
Myocardial infarction (MI)
0.85%
0.71–1.04
Observational data: associations, not effects.
Further findings
Risk of MACE by treatment
| SHR (CI) | P value | ||
|---|---|---|---|
| NSAIDs | 0.39 (0.32–0.50) | P < 0.001 | |
| Anti-TNF | 0.61 (0.46–0.80) | P < 0.001 | |
| Anti-IL17Not associated with a lower risk | 2.10 (0.79–5.57) | ||
| 0.20.5125Subdistribution hazard ratio (log scale) |
Original publication
Impact of NSAIDs on 8-year cumulative incidence of major cardiovascular events in patients with ankylosing spondylitis: a nationwide study. Rheumatology (Oxford). Published 8 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →