Increased serum levels of sCD40L were associated with rapidly progressive interstitial lung disease in idiopathic inflammatory myopathies
Authors' conclusion
We established a predictive model for IIMs-RPILD, which provided a clue that coagulopathy might exist in IIMs-RPILD and could help to better treat patients with RPILD.
Study context
- Population
- Patients with IIM-associated ILD
- Participants
- 80 patients
- Exposure
- RPILD vs stable-ILD in IIM-associated ILD
- Outcome
- Risk factors for 6-month mortality and predictors for a predictive model for RPILD
- Follow-up
- 6 months
Methodological detailsunivariable and adjusted multivariable Cox regression, predictive model
- Univariable and adjusted multivariable Cox regression
- Predictive model
Main finding
As reported in the abstract
Independent risk factors of short-term mortality in RPILD (multivariable Cox regression)
- Albumin<32.4 g/L: independent risk factor
- sCD40L<1658.55 pg/ml: independent risk factor
Observational data: associations, not effects.
Further findings
Odds for RPILD by SMAD score (sCD40L>1054 pg/ml, anti-MDA5 positivity, albumin<32.4 g/L, D-dimer>0.865 mg/L)
- SMAD score 1
- 26.9%
- SMAD score 2
- 66.7%
- SMAD score 3
- 91.7%
- SMAD score 4
- 100%
- SMAD score 0
6-month survival by SMAD severity
- Mild (SMAD score 0)
- 100%
- Moderate (SMAD score 1 and 2)
- 79.5%
- Severe (SMAD score 3 and 4)
- 20%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Increased serum levels of sCD40L were associated with rapidly progressive interstitial lung disease in idiopathic inflammatory myopathies. Clin Exp Rheumatol. Published 30 May 2022. doi:10.
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