Adipose tissue distribution is associated with cardio-metabolic alterations in adult patients with juvenile-onset dermatomyositis
Authors' conclusion
Adults with JDM showed more central adiposity and cardio-metabolic alterations than controls.
Study context
- Population
- Adults with juvenile-onset DM (mean age 31.7 y, 51% female), examined mean 22.7 y (SD 8.9 y) after disease onset
- Participants
- 39 vs 39
- Exposure
- Adults with JDM vs age/sex-matched controls
- JDMn = 39
- Controlsn = 39reference
- Outcome
- Adipose tissue distribution (VAT, g, by DXA)
Methodological detailsage/sex-matched controls
- Age/sex-matched controls
Main finding
As reported in the abstract
VAT
- Patients exhibited a 2.4-fold increase in visceral adipose tissue (VAT) compared with controls (P-values ≤ 0.05)
Observational data: associations, not effects.
Further findings
Cardiac dysfunction (systolic and/or diastolic)
P = 0.07
| Outcome | JDM | Controls |
|---|---|---|
| Metabolic syndrome | 25.7% | 0 events |
HDL-cholesterol
- Reduced HDL-cholesterol in patients vs controls (P-values ≤ 0.05)
VAT correlates in patients
- VAT levels correlated with age, disease duration and occurrence of metabolic syndrome and cardiac dysfunction
Independent associations with cardiac dysfunction in patients
- Lipodystrophy tended to be independently associated
- P = 0.02
- Male sex tended to be independently associated
- P = 0.04
- For secondary aims, P ≤0.01 considered significant
Original publication
Adipose tissue distribution is associated with cardio-metabolic alterations in adult patients with juvenile-onset dermatomyositis. Rheumatology (Oxford). Published 16 May 2022. doi:10.
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