Interstitial lung disease in adult patients with anti-NXP2 antibody positivity: a multicentre 18-month follow-up study
Authors' conclusion
Adult patients with anti-NXP2 antibody positivity mainly had dermatomyositis. Concurrent ILD is not uncommon, but clinical manifestations are often latent. NSIP and/or OP are the most common patterns. ILD is more common in older age groups.
Study context
- Population
- Hospitalised adults with anti-NXP2 antibody positivity at three tertiary rheumatology centres, June 2017 to December 202029 with DM
- Participants
- 33 adults
- Exposure
- Interstitial lung disease (ILD) vs non-ILD in anti-NXP2-positive patients
- ILDn = 14
- Outcome
- Pulmonary lesions
Methodological detailsmulticentre, three tertiary rheumatology centres
- Multicentre
- Three tertiary rheumatology centres
Main finding
As reported in the abstract
- ILD (various types)
- 14/33, 42.4%
- Bilateral pleural effusion
- 2/33, 6.1%
- Diffuse alveolar haemorrhage
- 1/33, 3%
- Respiratory symptoms at onset
- 3/33, 9.1%
- Non-specific interstitial pneumonia (NSIP) and/or organising pneumonia (OP) among ILD
- 11/14, 78.6%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| All-cause deathNo association | log-rank p=0.84 |
- Age, ILD vs non-ILD — Age the only independent predictor for ILD (logistic regression) · ILD older
- P = 0.008 · P = 0.002
All-cause death
- None of the deaths directly related to ILD
Original publication
Interstitial lung disease in adult patients with anti-NXP2 antibody positivity: a multicentre 18-month follow-up study. Clin Exp Rheumatol. Published 18 February 2022. doi:10.
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