Increased serum level of IL-6 predicts poor prognosis in anti-MDA5-positive dermatomyositis with rapidly progressive interstitial lung disease
Authors' conclusion
Our study demonstrated that increased level of serum IL-6 (≥ 13.41pg/mL) and severe lymphopenia were promising predictors of 6-month all-cause mortality and the occurrence of RP-ILD in anti-MDA5-positive DM patients.
Study context
- Population
- Patients with anti-MDA5-positive DM (with rapidly progressive interstitial lung disease (RP-ILD)), two cohorts
- Participants
- 168 patients2 cohorts
- Exposure
- Group 1 vs Group 2 vs Group 3
- Outcome
- Predictors of 6-month all-cause mortality and RP-ILD
- Follow-up
- 6 months
Methodological detailstwo cohorts, univariate and multivariate Cox regression, group-based trajectory modeling
- Two cohorts
- Univariate and multivariate Cox regression
- Group-based trajectory modeling
Main finding
As reported in the abstract
Independent predictors (multivariate Cox regression)
- Independent predictors of 6-month all-cause mortality: IL-6 ≥ 13.41pg/mL, lymphocytes < 0.5 × 109 /L, lymphocytes 0.5 to 1.0 × 109 /L, older age, elevated LDH
- Independent predictors of RP-ILD: IL-6 ≥ 13.41pg/mL, lymphocytes < 0.5 × 109 /L, lymphocytes 0.5 to 1.0 × 109 /L
Observational data: associations, not effects.
Further findings
- Mortality by lymphocyte trajectory group (first week after admission) — Group 1
- 90.7%
Mortality by lymphocyte trajectory group (first week after admission)
- Group 1 showed the highest mortality, all experiencing RP-ILD
Lung tissue findings
- Increased IL-6 expression in lung tissue in two cases with RP-ILD vs two without
- Increased infiltration of CD4+ and CD8+ T cells, particularly CD8+, in lung tissue with RP-ILD
Original publication
Increased serum level of IL-6 predicts poor prognosis in anti-MDA5-positive dermatomyositis with rapidly progressive interstitial lung disease. Arthritis Res Ther. Published 28 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →