Increased risk of hip and major osteoporotic fractures in 8463 patients who have undergone stem cell transplantation, a Swedish population-based study
Authors' conclusion
Patients who underwent HSCT had an increased risk of both hip and major osteoporotic fracture compared with the Swedish population and occurred in 4.3% of patients.
Study context
- Population
- Adult (≥ 18 years) Swedish patients transplanted with hematopoietic stem cell transplantation (HSCT) 1997–2016
- Exposure
- Adult HSCT recipients vs all adults living in Sweden in the same period
- HSCTn = 8,463
- Allo-HSCTn = 1,865
- Outcome
- Risk of osteoporotic fractures (hip fracture and MOF)
Methodological detailspopulation-based, observed/expected ratios vs Swedish population
- Population-based
- Observed/expected ratios vs Swedish population
Main finding
As reported in the abstract
- Hip fractures, total study group (1.1% both in males and females)
- 90
- Major osteoporotic fractures (MOF), total study group (3.2% in men and 6.0% in women)
- 361
- Observed/expected hip fracture ratio, women
- 1.99 (95% CI 1.39-2.75)
- Observed/expected hip fracture ratio, men
- 2.54 (95% CI 1.91-3.31)
- Observed/expected MOF ratio, women
- 1.36 (CI 1.18-1.56)
- Observed/expected MOF ratio, men
- 1.61 (CI 1.37-1.88)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate |
|---|---|
| Hip fracture and MOF in allo-HSCT (from 2005 onwards)Allo-HSCT vs Swedish population | observed/expected hip fracture 5.24 (95% CI 3.28–7.93) |
| Hip fracture and MOF in allo-HSCT (from 2005 onwards)Allo-HSCT vs Swedish population | observed/expected MOF 2.08 (95% CI 1.63–2.62) |
Time to fracture after allo-HSCT
- Hip fracture, mean years after allo-HSCT
- 2.7
- MOF, mean years after allo-HSCT
- 2.5
Graft-versus-host disease (GVHD) and fracture risk
- GVHD was not associated with an increased risk of fracture
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Increased risk of hip and major osteoporotic fractures in 8463 patients who have undergone stem cell transplantation, a Swedish population-based study. Osteoporos Int. Published 8 July 2024. doi:10.
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