Vasculitis & polymyalgia rheumatica
Increased mortality rate in Takayasu arteritis is largely driven by cardiovascular disease: a cohort study
Main finding · Mortality, SMR vs general populationResult — go to the resultSMR 17.29 95% CI 8.95–30.11Authors' conclusion
Patients with TAK had an elevated risk of mortality as compared with the general population. Cardiovascular disease was the leading cause of death in TAK.
Study context
- Population
- Patients with TAK (159 females, mean follow-up 44.36 months)12 deaths
- Participants
- 224 patients
- Exposure
- TAK vs general population
- TAKn = 224
- Outcome
- Mortality risk (SMR vs general population), causes and predictors of mortality
Methodological detailsKaplan-Meier survival, age- and sex-standardized mortality ratio, Cox regression or exponential parametric regression
- Kaplan-Meier survival
- Age- and sex-standardized mortality ratio
- Cox regression or exponential parametric regression
Main finding
Mortality, SMR vs general population
SMR
17.29
95% CI 8.95–30.11
As reported in the abstract
- Survival at 1, 2, 5 and 10 years
- 97.34%, 96.05%, 93.93% and 89.23%
- Deaths, mostly due to CVD (HF, MI, stroke)
- 12
Observational data: associations, not effects.
Further findings
Predictors of mortality (Cox regression or exponential parametric regression)
| HR (95% CI) | ||
|---|---|---|
| Earlier age at disease onsetAssociated with elevated mortality risk | 0.90 (0.83–0.98) | |
| Higher disease activity scores: ITAS2010Associated with elevated mortality risk | 1.15 (1.05–1.25) | |
| Higher disease activity scores: DEI.TAKAssociated with elevated mortality risk | 1.18 (1.08–1.29) | |
| Any serious infectionsAssociated with elevated mortality risk | 5.43 (1.72–17.12) | |
| Heart failureAssociated with elevated mortality risk | 7.83 (2.17–28.16) | |
| Coeliac trunk involvement at baselineAssociated with elevated mortality risk | 4.01 (1.26–12.75) | |
| 0.050.21520Hazard ratio (log scale) |
| Outcome | HR (95% CI) | |
|---|---|---|
| Predictors of mortality (Cox regression or exponential parametric regression)Pediatric-onsetvs Adult-onsetAssociated with elevated mortality risk | 5.51 (1.57–19.32) | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Increased mortality rate in Takayasu arteritis is largely driven by cardiovascular disease: a cohort study. Rheumatology (Oxford). Published 2 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →