Increased mortality in patients with rheumatoid arthritis (RA)-associated interstitial lung disease: data from a French administrative healthcare database
An erratum to this article was published (RMD Open, 30 Jan 2024 ↗)
Main finding · Mortality, after matchingResult — go to the resultHazard ratio 3.4 95% CI 3.1–3.9Authors' conclusion
In this nationwide cohort study, RA-ILD was associated with increased mortality rate (vs in patients with RA without ILD), notably for those aged <75 years, those whose ILD preceded RA onset and men.
Study context
- Population
- Adults with RA (ICD-10 M05, M06.0, M06.8, M06.9) in the French national claims database (Système National des Données de Santé), 2013–2018patients with RA
- Participants
- 173,132 adults
- Exposure
- RA with interstitial lung disease (ILD) vs RA without ILD
- Outcome
- Mortality rate
Methodological detailsnationwide, French national claims database, matched 1:1 for age, sex, age at RA-ILD onset and RA duration, Cox proportional hazards regression
- Nationwide
- French national claims database
- Matched 1:1 for age, sex, age at RA-ILD onset and RA duration
- Cox proportional hazards regression
Main finding
Mortality, after matching
Hazard ratio
3.4
95% CI 3.1–3.9
RA-ILDvs RA without ILD
HR 3.4 (95% CI 3.1–3.9)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Mortality by age (subgroup)RA-ILDvs RA without ILDAged <75 years | 4.8 (3.9–5.9) | |
| Mortality by age (subgroup)RA-ILDvs RA without ILDAged ≥75 years | 3.0 (2.6–3.5) | |
| Mortality by timing of ILD onset (subgroup)RA-ILDvs RA without ILDILD onset before RA onset | 8.4 (5.5–13.0) | |
| Mortality by timing of ILD onset (subgroup)RA-ILDvs RA without ILDILD onset after RA onset | 2.9 (2.6–3.3) | |
| Mortality by sex (subgroup)RA-ILDvs RA without ILDMen | 5.2 (4.4–6.2) | |
| Mortality by sex (subgroup)RA-ILDvs RA without ILDWomen | 3.6 (3.0–4.2) | |
| 0.050.21520Hazard ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Increased mortality in patients with RA-associated interstitial lung disease: data from a French administrative healthcare database. RMD Open. Published 1 December 2023. doi:10.
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