Increased frequency of hepatic steatosis and fibrosis in patients with gout detected by transient elastography
Authors' conclusion
Despite not being associated with common gout comorbidities, fatty liver and liver fibrosis were common in this gout cohort
Study context
- Population
- Consecutive gout patients undergoing transient elastography (FibroScan) at a single centre, 11/1/2016 to 11/1/2021 (mean age 59.8 years; mean body mass index (BMI) 30.95 kg/m²)7 females · 40 males
- Participants
- 47 patients
- Outcome
- Non-alcoholic fatty liver disease (NAFLD) assessed by transient elastography: hepatic steatosis (CAP >238 dB/m) and fibrosis (E score >7)
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
As reported in the abstract
Hepatic steatosis (controlled attenuation parameter (CAP) >238 dB/m)
40
85.1%
Fibrosis (E score >7)
9
19.1%
Severe fibrosis (cirrhosis)
8
Observational data: associations, not effects.
Further findings
Associations of steatosis
- Steatosis associated with BMI
- r=0.53, p=0.0001
- Steatosis not associated with age, serum urate (SU), glucose, triglycerides, ALT, AST
Associations of fibrosis
- Fibrosis associated with age
- P = 0.03
- Fibrosis associated with known liver disease
- P = 0.003
- Fibrosis not associated with BMI, SU or comorbidities
FIB-4 score vs fibrosis score
- FIB-4 associated with fibrosis score
- r2=0.24, p=0.0009
- FIB-4 not associated with CAP, ALT or AST
Original publication
Increased frequency of hepatic steatosis and fibrosis in patients with gout detected by transient elastography. Clin Exp Rheumatol. Published 3 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →