Incidence of autoantibodies related to systemic autoimmunity in patients with severe COVID-19 admitted to the intensive care unit
Authors' conclusion
Patients with severe COVID-19 express AAbs more commonly compared to controls. No correlation was found between AAbs and disease outcome.
Study context
- Population
- Mechanically ventilated COVID-19 patients admitted to the intensive care unit (ICU), January 1st, 2021, to May 10th, 2021
- Participants
- 217 vs 117
- Comparison
- Mechanically ventilated COVID-19 patients in the ICU vs age- and sex-matched pre-pandemic healthy controls
- COVID-19n = 217
- Controlsn = 117reference
- Outcome
- Prevalence of AAbs
- Follow-up
- Within the first 48 hours upon ICU admission
Methodological detailsage- and sex-matched healthy controls, consecutive patients
- Age- and sex-matched healthy controls
- Consecutive patients
Main finding
As reported in the abstract
Any AAbs
P < 0.001
Observational data: associations, not effects.
Further findings
ANAs
P < 0.001
Anti-dsDNA
P = 0.01
Anti-CCP
P = 0.014
Anti-CL IgM
P = 0.005
Simultaneous reactivity against ≥3 autoantigens (AAb-positive patients)
- Patients with simultaneous reactivity against at least three autoantigens, of 174 AAb-positive
- 144 (82.8%)
ICU mortality
- The two groups did not differ in clinicoepidemiologic characteristics or ICU mortality ratio
AAbs and clinical outcome
- AAbs not found to correlate with the clinical outcome
Original publication
Incidence of autoantibodies related to systemic autoimmunity in patients with severe COVID-19 admitted to the intensive care unit. Clin Exp Rheumatol. Published 6 May 2022. doi:10.
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