Spondyloarthritis & psoriatic arthritis
Incidence and predictors of demyelinating disease in spondyloarthritis: data from a longitudinal cohort study
Authors' conclusion
The overall incidence of DD in this SpA cohort was low. Incident DD was higher in axSpA than in PsA. A diagnosis of axSpA, the presence of IBD, and ever-smoking predicted the development of DD. History of TNF-α inhibitor use was not found to be a predictor of DD in this cohort.
Study context
- Population
- Axial SpA (axSpA) and PsA patients from a longitudinal cohort databasewith follow-up data
- Participants
- 2,260 participants
- Exposure
- axSpA vs PsA; predictors of demyelinating disease (DD)
- Outcome
- Incidence of demyelinating disease (DD)
Methodological detailscompeting risk analysis, Cox regression (Fine and Gray's method)
- Competing risk analysis
- Cox regression (Fine and Gray's method)
Main finding
As reported in the abstract
Incidence of DD
DD events
18
Average IR of DD in SpA, per 100 000 persons per year
31
Observational data: associations, not effects.
Further findings
Incidence rate of DD at 20 years · competing risk analysis
P = 0.01
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Predictors of DD development (best predictive model)Ever-smokingvs Never-smokingCox regression with Fine and Gray's method | 2.918 (1.037–8.214) | P = 0.0426 | |
| Predictors of DD development (best predictive model)axSpAvs PsACox regression with Fine and Gray's method | 8.790 (1.242–62.182) | P = 0.0294 | |
| Predictors of DD development (best predictive model)Presence of IBDvs Absence of IBDCox regression with Fine and Gray's method | 5.698 (2.083–15.589) | P = 0.0007 | |
| 0.050.21520Hazard ratio (log scale) |
Predictors of DD development (best predictive model)
- History of TNF-α inhibitor therapy was not a predictor of DD
Original publication
Incidence and predictors of demyelinating disease in spondyloarthritis: data from a longitudinal cohort study. Rheumatology (Oxford). Published 4 October 2023. doi:10.
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