Vasculitis & polymyalgia rheumatica
Improved sensitivity of the skin pathergy test with polysaccharide pneumococcal vaccine antigens in the diagnosis of Behçet disease
Authors' conclusion
The SPT conducted using a 20G needle prick and PS-23 antigens was shown to be a promising tool for the diagnosis of BD owing to its improved sensitivity compared with the standard approach.
Study context
- Population
- Behçet disease (BD) patients, patients with other inflammatory diseases, recurrent aphthous stomatitis, and healthy controls
- Comparison
- Skin pathergy test (SPT) with PS-23 plus 20G needle prick vs standard single 20G needle prick
- Outcome
- Positive SPT: induration (≥2 mm) with erythema at 48 h
- Follow-up
- 48 h
Methodological detailssame observer, whole-blood assay in a subgroup
- Same observer
- Whole-blood assay in a subgroup
Performance
As reported in the abstract
Diagnostic performance of SPT in BD
| Test or model | Sensitivity | Specificity |
|---|---|---|
| PS-23 + 20G NEEDLE | 64.3% | 100% |
| SINGLE 20G PRICK | 4.8% | — not stated in the abstract |
Sensitivity
PS-23 + 20G NEEDLE64.3%
SINGLE 20G PRICK4.8%
Specificity
PS-23 + 20G NEEDLE100%
SINGLE 20G PRICK— not stated in the abstract
— not stated in the abstract
Further findings
Diagnostic performance in active BD (subgroup) · 48 h
Sensitivity
Specificity PS-23 + 20G NEEDLE 100%
Factors associated with a positive result
- A positive result was associated with active disease and no use of immunosuppressives
Cytokine production in whole-blood assay (WBA) (subgroup)
- Increased IL-1β and IL-1Ra production in response to PS-23 in active BD
- Cytokine response to lipopolysaccharide similar in all groups
Original publication
Improved sensitivity of the skin pathergy test with polysaccharide pneumococcal vaccine antigens in the diagnosis of Behçet disease. Rheumatology (Oxford). Published 28 September 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →