Lupus & antiphospholipid syndrome
Impairment of white matter microstructure and structural network in patients with systemic lupus erythematosus
Authors' conclusion
The study concludes that changes in WM microstructure and its structural network may contribute to the development of severe neuropsychiatric symptoms in SLE patients.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) and healthy controls140 SLE and 111 healthy controls (HCs) enrolled
- Participants
- 127 vs 102
- Exposure
- SLE vs healthy controls
- SLEn = 127
- HCsn = 102reference
- Outcome
- WM FA (tract-based spatial statistics (TBSS)) and structural network indicators (graph theory)
Methodological detailsdiffusion tensor imaging, tract-based spatial statistics, graph theory
- Diffusion tensor imaging
- Tract-based spatial statistics
- Graph theory
Main finding
As reported in the abstract
- Fractional anisotropy (FA) of 5 clusters (right RLIC, genu of corpus callosum (GCC), body of corpus callosum, splenium of corpus callosum (SCC)) significantly lower in SLE vs HCs
- P < 0.05 with threshold-free cluster enhancement corrected
Observational data: associations, not effects.
Further findings
Clinical correlations with white matter (WM) structure and network
- SLEDAI negatively correlated with FA in GCC; HAMD negatively correlated with FA in SCC and right RLIC
- P < 0.05
- SLEDAI negatively correlated with AUC of degree centrality (DC) and Enodal in left inferior frontal gyrus triangular
- q < 0.05 with false discovery rate corrected
- MMSE positively correlated with Enodal in left hippocampus
- P < 0.05
Original publication
Impairment of white matter microstructure and structural network in patients with systemic lupus erythematosus. Semin Arthritis Rheum. Published 22 December 2024. doi:10.
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