Vasculitis & polymyalgia rheumatica
Impact of concurrent glomerulonephritis on outcomes of diffuse alveolar haemorrhage in antineutrophil cytoplasmic antibody-associated vasculitis
Authors' conclusion
In our cohort, patients with DAH due to AAV without initial kidney involvement did not develop kidney involvement requiring dialysis or die during the follow-up period, though half of patients without initial evidence of kidney involvement subsequently developed it.
Study context
- Population
- Patients with diffuse alveolar haemorrhage (DAH) diagnosed by bronchoscopy and attributed to AAV over 8.5 years; End-stage kidney disease (ESKD) or prior kidney transplant excluded30 identified
- Participants
- 24 patients
- Exposure
- DAH in AAV without initial kidney involvement vs with kidney involvement
- No kidney involvementn = 6
- Kidney involvementn = 18reference
- Outcome
- Dialysis and death by initial kidney involvement
Main finding
As reported in the abstract
- Kidney involvement: required dialysis at qualifying bronchoscopy
- 8 of 18
- Dialysed during initial hospitalisation: declared ESKD in subsequent year
- 4
- Dialysed during initial hospitalisation: died in subsequent year
- 3
- Without initial dialysis requirement (n=16): developed kidney involvement requiring dialysis in subsequent year
- 0
- No kidney involvement: ultimately developed kidney involvement
- 3 of the six
Observational data: associations, not effects.
Original publication
Impact of concurrent glomerulonephritis on outcomes of diffuse alveolar haemorrhage in antineutrophil cytoplasmic antibody-associated vasculitis. Clin Exp Rheumatol. Published 11 July 2023. doi:10.
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