Immunoglobulin G and plasma glycome in early rheumatoid arthritis differ from matched controls and link less fat-free mass to an accelerated aging phenotype: an exploratory study
Main finding · GlycanAge (years)Result — go to the resultDifference 18.1 yearsAuthors' conclusion
Changes in the RA glycome occur early in the RA disease process and may be useful as biomarkers for RA diagnosis and monitoring.
Study context
- Population
- Patients with early rheumatoid arthritis (RA) and matched healthy controls; older (>60 y) patients with RA completing a diet and exercise interventiontwo cohorts
- Participants
- 10 / 10 / 20
- Exposure
- Early RA vs age-, sex- and BMI-matched healthy controls; RA before vs after a diet and exercise intervention
- Early RAn = 10
- Controlsn = 10reference
- Older RA (intervention)n = 20
- Outcome
- Alterations in immunoglobulin G (IgG) and plasma glycome and GlycanAge (glycome-based biological age) in early RA
Methodological detailstwo cohorts, age-, sex- and BMI-matched controls, diet and exercise intervention cohort
- Two cohorts
- Age-, sex- and BMI-matched controls
- Diet and exercise intervention cohort
Main finding
GlycanAge (years)
Difference
18.1 years
P = 0.03
By group
As reported in the abstract
Observational data: associations, not effects.
Further findings
GlycanAge association with cardiorespiratory fitness and fat-free mass in RA (n = 39), adjusted for chronologic age and sex
- V̇O2 peak (mL/kg/min), beta (p = 0.005)
- −1.66
- Fat-free mass (kg), beta (p = 0.004)
- −1.77
Diet and exercise intervention in RA (n = 20)
- Reductions in GlycanAge associated with increases in fat-free mass, Spearman rho (p = 0.04)
- −0.46
- Did not significantly alter glycome parameters
Original publication
Immunoglobulin G and plasma glycome in early rheumatoid arthritis differ from matched controls and link less fat-free mass to an accelerated aging phenotype: an exploratory study. Arthritis Res Ther. Published 21 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →