Immune Complexes Shape the Pathogenicity of Autoantibodies in Systemic Autoimmune Diseases: Insights From an FcγRIIIA ‐Reporter Assay
Authors' conclusion
The FcγRIIIA-reporter assay enables precise quantification of pathogenic bioactivity of ICs in various systemic autoimmune diseases, providing complementary information to existing serological markers.
Study context
- Population
- Serum samples from healthy controls, infectious disease controls and patients with systemic lupus erythematosus (SLE), Sjögren disease, MCTD, IIM, SSc and RA
- Participants
- 56 / 12 / 175 / 71 / 22 / 73 / 107 / 51
- Exposure
- Serum IC bioactivity in systemic autoimmune diseases vs healthy and infectious disease controls
- Healthy controlsn = 56reference
- Infectious disease controlsn = 12
- SLEn = 175
- Sjögren diseasen = 71
- MCTDn = 22
- IIMn = 73
- SScn = 107
- RAn = 51
- Outcome
- Bioactivity of serum immune complexes (ICs) (FcγRIIIA-reporter assay) and its association with disease activity
Methodological detailsFcγRIIIA-reporter cell assay
- FcγRIIIA-reporter cell assay
Main finding
As reported in the abstract
Serum IC bioactivity
| Group | Sensitivity for disease activity | Specificity for disease activity |
|---|---|---|
| SLE | 81% | 69% |
SLE
Sensitivity for disease activity81%
Specificity for disease activity69%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Remission at 24 months, low vs not low FcγRIIIA-reporter response within initial 3 months90% vs 75% | P = 0.56 |
SLE with low anti-dsDNA levels: high IC bioactivity
- Higher risk of clinical symptoms incl. nephritis, arthritis and skin involvement; additive value in assessing SLE activity
Longitudinal: flares
- FcγRIIIA-reporter assay reflected flares more sensitively than conventional serological markers
Original publication
Immune Complexes Shape the Pathogenicity of Autoantibodies in Systemic Autoimmune Diseases: Insights From an FcγRIIIA ‐Reporter Assay. Arthritis Rheumatol. Published 22 April 2026. doi:10.
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