IL-10 and IFN-γ as markers for early recognition of pediatric systemic lupus erythematosus complicated with macrophage activation syndrome
Authors' conclusion
Compared with pSLE and pSLE-MAS with a single episode, pSLE with recurrent MAS has different clinical manifestations and responses to treatment, requiring intensive studies to elucidate the underlying pathogenic mechanisms. Elevated serum levels of IL-10 and IFN-γ may be correlated with pSLE with MAS and can serve as serum biomarkers for pSLE with MAS.
Study context
- Population
- Pediatric-onset SLE with and without macrophage activation syndrome (MAS), plus one case of recurrent MAS (9-year-old girl)plus 1 recurrent MAS case
- Participants
- 18 / 48 / 40
- Comparison
- pSLE with MAS vs active pSLE without MAS vs inactive pSLE
- pSLE with MASn = 18
- Active pSLE without MASn = 48reference
- Inactive pSLEn = 40
- Outcome
- Serum IL-10 and IFN-γ as markers of MAS in pSLE
Methodological detailsage- and sex-matched
- Age- and sex-matched
Main finding
As reported in the abstract
- IL-10 and IFN-γ levels significantly higher in pSLE with MAS than in pSLE without MAS, and significantly correlated with SLE and MAS laboratory features
- IL-10 > 7.25 pg/ml: high sensitivity for predicting MAS in pSLE
- IFN-γ > 6.7 pg/ml: high specificity for predicting MAS in pSLE
Observational data: associations, not effects.
Further findings
Recurrent MAS in pSLE (single case)
- Constitutional symptoms evident; traditional immunosuppressive therapies unable to prevent the next MAS episode
Original publication
IL-10 and IFN-γ as markers for early recognition of pediatric systemic lupus erythematosus complicated with macrophage activation syndrome. Rheumatology (Oxford). Published 18 December 2023. doi:10.
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