Diagnostic and prognostic role of synovial tissue analysis in juvenile idiopathic arthritis: a monocentric study
Authors' conclusion
Synovial tissue analysis might support the clinicians in the diagnostic approach of paediatric patients presenting with arthritis and guide the clinical management in JIA.
Study context
- Population
- Paediatric patients undergoing synovial biopsy between 1995 and 2020biopsy for diagnosis
- Participants
- 65 patients
- Outcome
- Diagnostic yield of synovial biopsy: patients correctly classified
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Synovial biopsy performed for diagnosis in 65 cases; patients correctly classified
79%
Observational data: associations, not effects.
Further findings
Histology (42 juvenile idiopathic arthritis (JIA) samples)
- No difference in synovial lining layers, subsynovial elementary lesions, fibrin deposit, Krenn Synovitis Score, inflammatory infiltrate score and pattern between JIA subsets or on treatment exposure
Immunohistochemistry (31 JIA samples): CD3 expression
- Higher CD3 expression in polyarticular vs oligoarticular subset
- P = 0.040
Original publication
Diagnostic and prognostic role of synovial tissue analysis in juvenile idiopathic arthritis: a monocentric study. RMD Open. Published 14 December 2023. doi:10.
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