Identifying two pathways to poor prognosis in patients with anti-MDA5 antibodies: insights from prognostic factor and cytokines analysis
Authors' conclusion
Two pathways leading to poor prognosis were identified in anti-MDA5-Ab-positive patients, each marked by specific cytokine abnormalities.
Study context
- Population
- Patients with anti-MDA5 antibodies whose serum was available31 with rapidly progressive interstitial lung disease (RP-ILD)
- Participants
- 35 patients
- Outcome
- Mortality: prognostic factors, prognostic factor groups and their association with cytokine levels
Methodological detailsCox regression and log-rank test, principal component analysis, factor and cluster analyses, correlation and path analyses, multiplex bead assay of serum cytokines
- Cox regression and log-rank test
- Principal component analysis, factor and cluster analyses
- Correlation and path analyses
- Multiplex bead assay of serum cytokines
Performance
As reported in the abstract
Prognostic factors and prognostic factor groups linked to mortality
Prediction model using C-reactive protein (CRP) (Group 1) and γ-GTP (Group 2): AUC, not inferior to previously reported models
0.84
Original publication
Identifying two pathways to poor prognosis in patients with anti-MDA5 antibodies: insights from prognostic factor and cytokines analysis. Arthritis Res Ther. Published 16 April 2025. doi:10.
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