Vasculitis & polymyalgia rheumatica
Human leucocyte antigens and Japanese patients with polymyalgia rheumatica: the protective effect of DRB1*09:01
Authors' conclusion
This study is the first to demonstrate predisposing associations of DRB1*04:05, SE, and DQB1*04:01, and protective associations of DRB1*09:01 and DQB1*03:03 with PMR in Japanese patients.
Study context
- Population
- Japanese patients with polymyalgia rheumatica (PMR) and controls
- Participants
- 270 vs 413
- Comparison
- Japanese PMR patients vs controls
- PMRn = 270
- Controlsn = 413reference
- Outcome
- Associations of HLA DRB1 and DQB1 allele carrier and genotype frequencies with PMR
Methodological detailsHuman leucocyte antigen (HLA) DRB1 and DQB1 genotyping, haplotype and logistic regression analyses
- HLA DRB1 and DQB1 genotyping
- Haplotype and logistic regression analyses
Main finding
As reported in the abstract
HLA allele associations with PMR
Odds ratio (95% CI)P value
DRB1*04:05predisposition
1.85(1.31–2.62)
P = 0.0006, Pc=0.0193DRB1*09:01protection
0.40(0.26–0.61)
P = 1.46×10-5, Pc=0.0004Shared epitope (SE)predisposition
2.11(1.54–2.88)
P = 3.07×10-6DQB1*03:03protection
0.52(0.35–0.77)
P = 0.0010, Pc=0.0140DQB1*04:01predisposition
1.82(1.28–2.58)
P = 0.0009, Pc=0.0140Observational data: associations, not effects.
Original publication
Human leucocyte antigens and Japanese patients with polymyalgia rheumatica: the protective effect of DRB1*09:01. RMD Open. Published 22 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →