How common is remission in rheumatoid factor-positive juvenile idiopathic arthritis patients? The multicenter Pediatric Rheumatology Academy (PeRA) research group experience
Authors' conclusion
During 2 years of treatment, 44% of RF-positive polyarthritis patients have inactive disease
Study context
- Population
- Rheumatoid factor (RF)-positive polyarticular juvenile idiopathic arthritis (JIA) followed for ≥ 6 months between 2017 and 2022 by the PeRA-Research Group45 female and 11 male
- Participants
- 56 participants
- Exposure
- Methotrexate (MTX) responsive vs MTX unresponsive
- MTX unresponsiven = 39
- Outcome
- Remission status (active vs inactive disease)
- Follow-up
- 24 months
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Active disease at 24 months
Still had active disease at 24 months, of 25 patients followed for 24 months
56%
Observational data: associations, not effects.
Further findings
- Subcutaneous MTX (preferred initial treatment) ineffective — MTX unresponsive
- 69.6%
Age at onset of RF-positive polyarthritis
- Median age at onset, years (IQR: 9.0-15.0 years)
- 13.2
Duration of follow-up
- Median follow-up, months (IQR: 19.5-75.7 months)
- 41.5
Joint involvement
- Symmetrical arthritis of the hand metacarpophalangeal and proximal interphalangeal joints commonly observed
Original publication
How common is remission in rheumatoid factor-positive juvenile idiopathic arthritis patients? The multicenter Pediatric Rheumatology Academy (PeRA) research group experience. Pediatr Rheumatol Online J. Published 20 July 2023. doi:10.
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