Spondyloarthritis & psoriatic arthritis
Hounsfield Units measured in low dose CT reliably assess vertebral trabecular bone density changes over two years in axial spondyloarthritis
Authors' conclusion
LdCT measurement of HU is a reliable method to assess two-year changes in trabecular bone density at each vertebra from C3-L5.
Study context
- Population
- Patients with radiographic axial spondyloarthritis (r-axSpA) from the multicentre two-year Sensitive Imaging in Ankylosing Spondylitis (SIAS) study1,053 vertebrae assessed
- Participants
- 49 patients
- Comparison
- Reader 1 vs reader 2
- Primary endpoint
- Inter-reader reliability of two-year change-from-baseline ldCT HU values per vertebra (ICC, SDC, Bland-Altman, agreement on direction of change and change >|SDC|)
- Follow-up
- Two years
Methodological detailsmulticentre, two independent readers, secondary use of the SIAS study
- Multicentre
- Two independent readers
- Secondary use of the SIAS study
Primary result
As reported in the abstract
Inter-reader reliability of two-year change-from-baseline HU per vertebra
Intraclass correlation coefficients (ICC)
0.91-0.99
Smallest detectable change (SDC)
6-10
Agreement on direction of change, per vertebral level C3 to L5
88-96%
Agreement on change >|SDC|, per vertebral level C3 to L5
58-94%
Further findings
Hounsfield Units (HU) mean change values over two years
- Range of mean change, reader 1
- −23 to 28
- Range of mean change, reader 2 (upper bound)
- 29
- Varied from −23 to 28 and 29 for reader 1 and 2, respectively
Original publication
Hounsfield Units measured in low dose CT reliably assess vertebral trabecular bone density changes over two years in axial spondyloarthritis. Semin Arthritis Rheum. Published 30 November 2022. doi:10.
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