Lupus & antiphospholipid syndrome
Hospitalized patients with positive antiphospholipid antibodies who have low complement levels are at increased risk for death—a retrospective cohort study
Main finding · MortalityResult — go to the resultOdds ratio 1.93 CI 1.63–2.27Authors' conclusion
Our study results indicate that low complement is associated with significantly higher mortality rates in admitted patients with elevated levels of anti-phospholipid antibodies.
Study context
- Population
- Patients hospitalized 2007–2021, for whatever reason, with at least one positive aPL and tested for complement (C3 or C4)32,286 tested for aPL
- Participants
- 6,800 patients
- Exposure
- Low complement vs normal complement levels
- Outcome
- Mortality
Methodological detailsconsecutive patients, multivariate analysis
- Consecutive patients
- Multivariate analysis
Main finding
As reported in the abstract
Odds ratio
1.93
CI 1.63–2.27
P < 0.001
Low complementvs Normal complement
OR 1.93 (CI 1.63–2.27); P < 0.001
Observational data: associations, not effects.
Further findings
DVT and PE rates
- Deep vein thrombosis and pulmonary emboli rates were similar
Original publication
Hospitalized patients with positive antiphospholipid antibodies who have low complement levels are at increased risk for death—a retrospective cohort study. Lupus. Published 23 March 2023. doi:10.
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