Spondyloarthritis & psoriatic arthritis
HLA-B5 prevalence in patients with spondyloarthritis and impact on disease phenotype: a multicentric case–control study
Authors' conclusion
HLA-B51 was identified more frequently in patients with SpA compared with HC and was associated with recurrent oral ulcerations and juxta-articular radiographic erosions.
Study context
- Population
- Lebanese patients with spondyloarthritis (SpA) from three rheumatology clinics and healthy controls from blood donors
- Participants
- 86 / 65 / 15 / 6 / 120
- Comparison
- SpA patients vs healthy controls
- SpAn = 86
- axSpAn = 65
- Peripheral SpA (pSpA)n = 15
- Psoriatic arthritis (PsA)n = 6
- Healthy controls (HC)n = 120reference
- Outcome
- Prevalence of HLA-B51 and HLA-B52 in SpA patients vs HC
Methodological detailsmulticentre, consecutive enrolment, logistic regression
- Multicentre
- Consecutive enrolment
- Logistic regression
Main finding
As reported in the abstract
HLA-B51 prevalence
P = 0.016
Observational data: associations, not effects.
Further findings
HLA-B52 prevalence (numerically higher)
P = 0.230
Factors associated with HLA-B51 in SpA patients
- Recurrent oral ulcerations, OR
- 7.99 (95% CI 2.14, 29.84)
- Radiographic juxta-articular erosions, OR
- 7.65 (95% CI 1.14, 38.03)
HLA-B allele distribution
- HLA-B35, most dominant allele in both groups
- 18.7%
- HLA-B27 in SpA
- 15.7%
- HLA-B51 in SpA
- 13.4%
Original publication
HLA-B5 prevalence in patients with spondyloarthritis and impact on disease phenotype: a multicentric case–control study. Rheumatology (Oxford). Published 17 July 2024. doi:10.
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