Vasculitis & polymyalgia rheumatica
Higher risk profile among patients with TET2-mutated giant cell arteritis: a cluster analysis
Authors' conclusion
CH is prevalent among patients with GCA but does not differ significantly from controls or other autoimmune conditions. However, specific genetic profiles, particularly mutations in TET2 and JAK2, are associated with a higher risk cluster within the GCA cohort.
Study context
- Population
- Patients with giant cell arteritis (GCA), patients with other autoimmune diseases and control participants at three hospitals
- Participants
- 49 / 48 / 27
- Exposure
- GCA vs other autoimmune diseases vs controls
- GCAn = 49
- Other autoimmune diseases (AIDs)n = 48
- Controlsn = 27reference
- Outcome
- Prevalence of clonal haematopoiesis (CH)
Methodological detailsmulticentre (three hospitals), next-generation sequencing, cluster analysis
- Multicentre (three hospitals)
- Next-generation sequencing
- Cluster analysis
Main finding
As reported in the abstract
CH prevalence
Observational data: associations, not effects.
Further findings
Most commonly mutated genes in GCA and controls
- DNMT3A and TET2
Cluster analysis within GCA
- Two distinct clusters; one with higher prevalence of TET2 and JAK2 variants, associated with worse prognosis
Original publication
Higher risk profile among patients with TET2-mutated giant cell arteritis: a cluster analysis. RMD Open. Published 10 December 2024. doi:10.
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