Healthy dietary pattern and risk of rheumatoid arthritis: A systematic review and meta-analysis
Pooled result · Incident RA, healthy overall dietary patternResult — go to the resultOdds ratio 0.54 95 % CI 0.32–0.91Authors' conclusion
In observational studies, healthy dietary pattern is associated with reduced risk of incident RA.
Study context
- Population
- Case-control and cohort studies of validated diet preceding a validated rheumatoid arthritis (RA) definition12 studies (8 independent)
- Comparison
- Healthy dietary pattern vs less healthy diet
- Outcome
- Incident RA
Methodological detailsrandom effects models, adjusted ORs, subgroup analyses, Newcastle-Ottawa Scale risk of bias, GRADE certainty assessment, Risk of bias: 3 studies low, 3 moderate, 3 high, 3 very high
- Random effects models
- Adjusted ORs
- Subgroup analyses
- Newcastle-Ottawa Scale risk of bias
- GRADE certainty assessment
- Risk of bias: 3 studies low, 3 moderate, 3 high, 3 very high
Pooled result
Incident RA, healthy overall dietary pattern
Odds ratio
0.54
95 % CI 0.32–0.91
Healthy dietary pattern
OR 0.54 (95 % CI 0.32–0.91)
As reported in the abstract
Further pooled results
Incident RA by dietary pattern
| OR (95% CI) | ||
|---|---|---|
| Anti-inflammatoryAll showed lower point estimates for RA | 0.56 (0.31–0.99) | |
| MediterraneanAll showed lower point estimates for RA | 0.88 (0.78–0.99) | |
| HEIAll showed lower point estimates for RA | 0.60 (0.25–1.47) | |
| 0.20.5125Odds ratio (log scale) |
Incident RA, studies with lowest risk of bias only (sensitivity analysis)
- Lower RA risk, OR
- 0.84 (95% CI 0.76-0.94, I2=0 %)
Original publication
Healthy dietary pattern and risk of rheumatoid arthritis: A systematic review and meta-analysis. Semin Arthritis Rheum. Published 29 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →