Lupus & antiphospholipid syndrome
Hashimoto’s thyroiditis increases the risk of new-onset systemic lupus erythematosus: a nationwide population-based cohort study
Authors' conclusion
Our study showed an increased risk of SLE in the HT group after adjustment for baseline characteristics, comorbidities, and medical confounders compared with the reference group.
Study context
- Population
- Taiwan National Health Insurance Research Database: patients with Hashimoto's thyroiditis (HT) and matched individuals without HT
- Participants
- 15,512 vs 31,024
- Exposure
- HT vs propensity score matched non-HT
- HTn = 15,512
- non-HTn = 31,024reference
- Outcome
- New-onset SLE
Methodological detailsnationwide population-based, propensity score matched 1:2, Cox proportional hazards models
- Nationwide population-based
- Propensity score matched 1:2
- Cox proportional hazards models
Main finding
As reported in the abstract
SLE
IRR of systemic lupus erythematosus (SLE)
3.58
95% CI 2.43–5.28p < 0.01
Observational data: associations, not effects.
Further findings
SLE, sensitivity analyses
- Sensitivity analysis aHR
- 4.35 (3.28-5.76) (CI)
- Sensitivity analysis aHR
- 4.39 (3.31-5.82) (CI)
- Sensitivity analysis aHR
- 5.11 (3.75-6.98) (CI)
- Sensitivity analysis aHR
- 4.70 (3.46-6.38) (CI)
- Consistent with the results of the main model
Original publication
Hashimoto’s thyroiditis increases the risk of new-onset systemic lupus erythematosus: a nationwide population-based cohort study. Arthritis Res Ther. Published 9 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →