Autoinflammatory & rare systemic diseases
Gut microbiota alterations are associated with phenotype and genotype in familial Mediterranean fever
Authors' conclusion
The gut microbiota of FMF patients correlates with disease characteristics and severity, with an increase in pro-inflammatory taxa in the most severe patients.
Study context
- Population
- Large cohort of FMF patients (AA amyloidosis n = 17, hepatopathy n = 5, colchicine resistance n = 27, biotherapy n = 10) and healthy controls
- Participants
- 119 vs 61
- Exposure
- FMF patients vs healthy controls
- FMFn = 119
- Healthy controlsn = 61reference
- Outcome
- Gut microbiota composition in relation to disease characteristics
Methodological details16 s rRNA gene sequencing, multivariable association with linear models (MaAslin2), bacterial network analysis
- 16 s rRNA gene sequencing
- Multivariable association with linear models (MaAslin2)
- Bacterial network analysis
Main finding
As reported in the abstract
Gut microbiota composition
- FMF patients differ from controls in having increased pro-inflammatory bacteria, such as the Enterobacter, Klebsiella and Ruminococcus gnavus group
- Disease characteristics and colchicine resistance correlated with homozygous mutations and were associated with specific microbiota alteration
- Colchicine treatment associated with expansion of anti-inflammatory taxa such as Faecalibacterium and Roseburia
- FMF severity associated with expansion of the Ruminococcus gnavus group and Paracoccus
- Colchicine-resistant patients: altered bacterial network structure, with decreased intertaxa connectivity
- Adjusted on age, sex, genotype, AA amyloidosis, hepatopathy, colchicine intake, colchicine resistance, biotherapy, CRP levels, and number of daily faeces
Observational data: associations, not effects.
Original publication
Gut microbiota alterations are associated with phenotype and genotype in familial Mediterranean fever. Rheumatology (Oxford). Published 4 July 2023. doi:10.
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