Systemic sclerosis & Raynaud's
Gut microbiome profiling in systemic sclerosis: a metagenomic approach
Authors' conclusion
Using metagenomic sequencing, our study further underlines distinct alterations in microbiota profiling among Asian SSc patients.
Study context
- Population
- Adult Asian female systemic sclerosis (SSc) patients (5 diffuse, 18 limited; median age 54 years; median disease duration 3.3 years) and female healthy controls (HC) (median age 56 years)23 SSc, 19 HC
- Participants
- 12 / 11 / 19
- Exposure
- SSc patients vs healthy controls; SSc on immunosuppressive drugs vs no immunosuppressive drugs
- SSc (on immunosuppressive (On-IS))n = 12
- SSc (No-IS)n = 11
- HCn = 19reference
- Outcome
- Gut microbiome diversity and taxonomic profile
Methodological detailsage-and-sex-matched healthy controls, metagenomic sequencing of stool DNA
- Age-and-sex-matched healthy controls
- Metagenomic sequencing of stool DNA
Main finding
As reported in the abstract
- Species level: increased several Lactobacillus, Bifidobacterium and Coprococcus species in SSc; increased Odoribacter, Bacteroides and Prevotella species in HC
- KEGG pathway analysis: distinct differences between SSc vs HC, and between SSc (No-IS) and SSc (On-IS)
- SSc vs HC: P = 0.014
- SSc (No-IS) vs HC: P = 0.006
- SSc vs HC: P = 0.307
- SSc vs HC: all p<0.001
Observational data: associations, not effects.
Original publication
Gut microbiome profiling in systemic sclerosis: a metagenomic approach. Clin Exp Rheumatol. Published 2 October 2022. doi:10.
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