Genetic architecture underlying IgG-RF production is distinct from that of IgM-RF
Authors' conclusion
We found a unique genetic architecture for IgG-RF(-) RA, which showed a strong association with a SE allele not frequent in the Japanese population but the most frequent SE allele in Europeans.
Study context
- Population
- RA subjects with detailed autoantibody (IgG-RF, IgM-RF, ACPA) data, and healthy controls; Japanese population743 RA patients · 2008 healthy controls
- Comparison
- IgG-RF vs IgG-RF RA subsets, vs healthy controls
- Healthy controlsn = 2,008reference
- Outcome
- Associations between presence or levels of autoantibodies (IgG-RF, IgM-RF, ACPA) and HLA-DRB1 alleles
Methodological detailscase-control
- Case-control
Main finding
As reported in the abstract
Association with HLA-DRB1 SE alleles by IgG-RF status
- Both IgG-RF(+) and IgG-RF(-) RA showed comparable associations with SE alleles, not observed for the other autoantibodies
- Association in IgG-RF(+) subset solely driven by HLA-DRB1*04:05 (most frequent SE allele in Japanese)
- In IgG-RF(-) subset, HLA-DRB1*04:05 and HLA-DRB1*04:01 (most frequent SE allele in Europeans) were main drivers
- Associations irrespective of ACPA presence
Observational data: associations, not effects.
Original publication
Genetic architecture underlying IgG-RF production is distinct from that of IgM-RF. Rheumatology (Oxford). Published 17 October 2022. doi:10.
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