Association Between Rheumatoid Arthritis Disease Activity and Periodontitis Defined by Tooth Loss: Longitudinal and Cross‐Sectional Data From Two Observational Studies
Authors' conclusion
Although we observed an association between tooth loss and disease activity scores and inflammation markers in early and established RA, longitudinal results suggest that tooth loss does not hamper treatment response.
Study context
- Population
- Patients with early arthritis (Course And Prognosis of Early Arthritis (CAPEA) cohort) and with established rheumatoid arthritis (RA) (German National Database)1,124 CAPEA
- Exposure
- Higher vs lower tooth loss
- Outcome
- Disease activity (DAS28-ESR), SJC, ESR and CRP over time by tooth loss
- Follow-up
- Baseline, 3, 6, 12, 18 and 24 months
Methodological detailstwo observational studies, longitudinal early arthritis cohort (CAPEA), cross-sectional national database (NDB), linear mixed regression models, adjusted for age, sex, smoking, seropositivity, education level and disease duration (NDB only)
- Two observational studies
- Longitudinal early arthritis cohort (CAPEA)
- Cross-sectional national database (NDB)
- Linear mixed regression models
- Adjusted for age, sex, smoking, seropositivity, education level and disease duration (NDB only)
Main finding
As reported in the abstract
Early arthritis (CAPEA), longitudinal
- Tooth loss associated with higher disease activity and ESR values over time
- Inflammatory markers decreased comparably across tooth loss categories
Observational data: associations, not effects.
Further findings
Established RA (NDB), cross-sectional
- Disease activity and inflammation markers but not swollen joint count (SJC) significantly higher with more tooth loss
GC use (CAPEA)
- GC use higher with more tooth loss; dose reduction similar across tooth loss categories
Original publication
Association Between Rheumatoid Arthritis Disease Activity and Periodontitis Defined by Tooth Loss: Longitudinal and Cross‐Sectional Data From Two Observational Studies. Arthritis Care Res (Hoboken). Published 11 October 2022. doi:10.
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