Distinct HLA Associations for Antibody Multireactivity With Citrulline‐Containing Type II Collagen Epitopes Versus More Limited Antibody Reactivity With Citrulline‐Containing IgG Epitopes in Rheumatoid Arthritis
Authors' conclusion
Different HLA alleles may contribute to the different reactivity patterns of promiscuous anticitrullinated collagen antibodies and more private RA-associated RFs.
Study context
- Population
- ACPA+RF+ participants with rheumatoid arthritis (RA)ACPA+RF+
- Participants
- 100 participants
- Exposure
- HLA alleles in RA participants with high vs low IgG binding to citrulline-containing peptides, and with multireactivity vs limited reactivity
- Outcome
- Association of HLA alleles with ACPA reactivity patterns (serum IgG binding to 10 citrulline-containing peptides from Type II collagen and IgG1)
Methodological detailsHLA genotyping, ELISA, Fisher's exact test
- HLA genotyping
- ELISA
- Fisher's exact test
Main finding
As reported in the abstract
HLA associations with ACPA reactivity patterns
- Serum IgG multireactivity for citrulline-glycine motif-containing collagen peptides was high, at least partially due to promiscuous antibodies
- HLA-DQA1*01:02 present in more participants with anticitrullinated collagen antibodies and multireactive sera
- Serum multireactivity low for IgG1-derived peptides, due at least in part to more private antibodies
- Shared epitope-containing HLA-DRB1*04:01 present more frequently in participants with RA-associated RFs irrespective of the citrulline-serine motif, and less frequently in those with anticitrullinated collagen antibodies
- Several HLA alleles associated with specific antibody reactivities
Observational data: associations, not effects.
Original publication
Distinct HLA Associations for Antibody Multireactivity With Citrulline‐Containing Type II Collagen Epitopes Versus More Limited Antibody Reactivity With Citrulline‐Containing IgG Epitopes in Rheumatoid Arthritis. Arthritis Rheumatol. Published 11 January 2026. doi:10.
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