Collagen-binding integrin α11β1 contributes to joint destruction in arthritic human tumour necrosis factor transgenic (hTNFtg) mice
Authors' conclusion
Integrin α11 levels are increased in RA, and its deficiency notably diminishes joint destruction in hTNFtg mice
Study context
- Population
- Synovial tissue and fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) and OA patients; hTNFtg and wild-type mice
- Comparison
- Itga11-/-hTNFtg vs hTNFtg mice
Methodological details3D organoid coculture model, Itga11-/- crossed with hTNFtg mice, µCT and histology
- 3D organoid coculture model
- Itga11-/- crossed with hTNFtg mice
- µCT and histology
Main finding
As reported in the abstract
- Strong α11 expression in RA synovium, particularly in sublining clusters of FLS within fibroid-type synovial tissue, at focal adhesions of arthritic FLS and at invasion sites in the 3D coculture model
- Significantly reduced cartilage degradation, bone erosions and FLS attachment to cartilage in Itga11-/-hTNFtg vs hTNFtg mice
- α11 deficiency in vitro: decreased RANKL/osteoprotegerin ratio, reduced TNFα-induced proteolytic degradation activity and signalling pathway activation
Original publication
Collagen-binding integrin α11β1 contributes to joint destruction in arthritic hTNFtg mice. Ann Rheum Dis. Published 14 August 2025. doi:10.
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