Frequency of joint inflammation is associated with local joint damage progression in rheumatoid arthritis despite long-term targeted treatment
Authors' conclusion
In RA, long-term cumulative local joint inflammation is associated with joint damage progression in the same joint.
Study context
- Population
- Patients with rheumatoid arthritis (RA) and available radiographs from the BeSt study, treated to target for a median of 10 years
- Participants
- 473 patients
- Primary endpoint
- Association between cumulative local joint swelling (% of visits) and radiographic damage (% of maximum Sharp-Van der Heijde score) in the same joint
Methodological detailstreat-to-target (DAS ≤2.4), generalised linear mixed model, joint-level analysis, Joints assessed for swelling and tenderness every 3 months; hand and foot radiographs yearly
- Treat-to-target (DAS ≤2.4)
- Generalised linear mixed model
- Joint-level analysis
- Joints assessed for swelling and tenderness every 3 months; hand and foot radiographs yearly
Primary result
As reported in the abstract
Cumulative local joint swelling and local radiographic damage progression
β
0.14
95% CI 0.13 to 0.15
Further findings
Cumulative local joint tenderness without concurrent swelling and local radiographic damage progression
- β
- 0.04 (95% CI 0.03 to 0.05)
- Less strongly associated
Original publication
Frequency of joint inflammation is associated with local joint damage progression in rheumatoid arthritis despite long-term targeted treatment. RMD Open. Published 6 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →