Osteoporosis & bone health

Fracture trends in Denmark from 1997 to 2021

Osteoporos IntPublished Retrospective cohort study

Authors' conclusion

Between 1997 and 2021 hip fracture IRs decreased, while vertebral fracture IRs increased.

Study context

Population
Adults with a fracture in 1997–2021 in the Danish National Patient Register (median age 55 years; 54% women)individuals with fractures
Participants
1,478,808 adults
Exposure
Women vs Men
Outcome
Annual age-standardized fracture IRs per 10,000 PY, 1997 vs 2021
Follow-up
1997-2021
Methodological detailsnationwide register-based, age-standardized incidence rates, Poisson regression
  • Nationwide register-based
  • Age-standardized incidence rates
  • Poisson regression

Main finding

As reported in the abstract

Major osteoporotic fracture IRs per 10,000 PY, 1997 to 2021
  • Women: decreased from 135.8 to 116.9 per 10,000 person-years (PY)
  • Men: decreased from 62.3 to 57.2 per 10,000 PY

Observational data: associations, not effects.

Further findings

Hip fracture incidence rates (IRs), 1997 to 2021

Women: decreased from 41.5 to 23.3
Men: decreased from 19.6 to 13.3

Vertebral fracture IRs, 1997 to 2021

Women: increased from 8.6 to 15.2
Men: increased from 7.8 to 11.9

Humerus and forearm fracture IRs · 1997 to 2021

Decreased slightly in women and men

Original publication

Fracture trends in Denmark from 1997 to 2021. Osteoporos Int. Published 6 November 2025. doi:10.1007/s00198-025-07746-0

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