Increased all-cause mortality following proximal humerus fractures in Danish adults: a register-based matched cohort study of 93,952 fracture cases and 469,760 controls
Authors' conclusion
Danish patients with PHF demonstrated substantially higher all-cause MRs than their controls, with the highest rates within the first 30 days after the fracture, especially among men.
Study context
- Population
- Adults with Proximal Humerus Fractures (PHF) in Denmark, Danish National Patient Register and Danish Civil Registration System, 1998–2018
- Participants
- 93,952 vs 469,760
- Exposure
- Adults with PHF vs age- and sex-matched controls from the general population
- PHFn = 93,952
- Controlsn = 469,760reference
- Outcome
- All-cause death at 30 and 90 days, one and two years (MRs per 1,000 persons; MRRs)
- Follow-up
- 30 and 90 days, one and two years
Methodological detailspopulation-based, matched 1:5 on age and sex, Poisson regression accounting for interactions
- Population-based
- Matched 1:5 on age and sex
- Poisson regression accounting for interactions
Main finding
As reported in the abstract
All-cause mortality, age 60-69 years · first 30 days post-fracture
MRR (males)
16.32
95% CI 14.47–18.40
males aged 60-69 years
MRR (women)
7.82
95% CI 7.15–8.54
women aged 60-69 years
Observational data: associations, not effects.
Further findings
All-cause mortality, 31–90 days post-fracture, age 60-69 years
- MRR, men (PHF vs controls)
- 6.75 (95% CI: 6.07-7.52)
- MRR, women (PHF vs controls)
- 3.87 (95% CI: 3.58-4.19)
All-cause mortality, after one year · 1–2 years
- MRR stabilized and remained relatively unchanged throughout the two-year follow-up
Original publication
Increased all-cause mortality following proximal humerus fractures in Danish adults: a register-based matched cohort study of 93,952 fracture cases and 469,760 controls. Osteoporos Int. Published 22 August 2025. doi:10.
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