Vasculitis & polymyalgia rheumatica
Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography in polymyalgia rheumatica: an observational study
Authors' conclusion
The number of hypermetabolic sites or SUVmax quantification might be useful for PMR diagnosis, and CSTs might affect the results of 18F-FDG PET/CT.
Study context
- Population
- Individuals with polymyalgia rheumatica (PMR) who underwent 18F-FDG PET/CT, and controls123 PMR patients analysed
- Exposure
- New-onset PMR vs controls; CST-naive vs CST-using PMR
- New-onset PMRn = 85
- Controlsn = 75reference
- CSTsn = 37
- Outcome
- Usefulness of 18F-FDG PET/CT for PMR diagnosis: number of sites with significant FDG uptake, mean SUVmax and highest SUVmax per patient
Methodological detailscontrolled, 16 sites assessed per patient
- Controlled
- 16 sites assessed per patient
Main finding
As reported in the abstract
Number of sites with significant FDG uptake
| Group | Value | Sensitivity (cut-off 5 hypermetabolic sites) | Specificity (cut-off 5 hypermetabolic sites) |
|---|---|---|---|
| New-onset PMR | mean 11.3 (SD 3.3) | 96.5% | 100% |
| Controls | mean 0.9 (SD 1.1) |
Value
New-onset PMRmean 11.3 (SD 3.3)
Controlsmean 0.9 (SD 1.1)
Sensitivity (cut-off 5 hypermetabolic sites)
New-onset PMR96.5%
Controls— not stated in the abstract
Specificity (cut-off 5 hypermetabolic sites)
New-onset PMR100%
Controls— not stated in the abstract
- New-onset PMR vs Controls: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | CST-naive | CSTs | P value |
|---|---|---|---|
| Large-vessel vasculitisCSTs vs CST-naive | 8% | 27% | P < 0.01 |
- CRP level, CST-naive vs CST use · significantly higher in CST-naive
- P < 0.001
- Number of sites with significant FDG uptake, CST-naive vs CST use · significantly higher in CST-naive
- P < 0.001
- SUVmax scores, CST-naive vs CST use · significantly higher in CST-naive
- P < 0.01
Total SUVmax score for PMR diagnosis, cut-off of 3
- Sensitivity (best, cut-off of 3)
- 92.6%
- Specificity (best, cut-off of 3)
- 86.1%
Original publication
Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography in polymyalgia rheumatica: an observational study. Clin Exp Rheumatol. Published 16 August 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →