Fine particulate matter air pollution and anti-nuclear antibodies
Authors' conclusion
PM2.5 exposure was associated with ANA positivity at high titres.
Study context
- Population
- General population, Ontario Health Study cohort (sera collected 2010–2013)
- Participants
- 3,548 participants
- Exposure
- Highest vs lowest quartile of ambient PM2.5 exposure
- Outcome
- ANA positivity (indirect immunofluorescence on HEp-2 cells) at titre thresholds
Methodological detailsrandom sample of a general population cohort, multivariable logistic regression
- Random sample of a general population cohort
- Multivariable logistic regression
Main finding
As reported in the abstract
ANA positivity by titre, highest vs lowest quartile of PM2.5
Highest quartile vs Lowest quartileOdds ratio (95% CI)
ANA titre ≥1:640
1.46(1.02–2.10)
ANA titre ≥1:1280
1.54(1.06–2.60)
Observational data: associations, not effects.
Further findings
ANA positivity with PM2.5 as a continuous variable
- OR always >1.00, increasing with ANA titre, but CIs always contained unity at any titre threshold
Original publication
Fine particulate matter air pollution and anti-nuclear antibodies. Rheumatology (Oxford). Published 22 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →