Fibroblast growth factor receptor 1 as a potential marker of terminal effector peripheral T helper cells in rheumatoid arthritis patients
Authors' conclusion
Our study provides evidence that FGFR1 marks terminal effector Tph cells in patients with RA.
Study context
- Population
- RA patients (peripheral blood and synovium) and healthy controls
- Comparison
- RA patients vs healthy controls
- Outcome
- Characterisation of FGFR1-positive CD4+ T cells in RA patients
Methodological detailssingle-cell RNA sequencing, flow cytometry
- Single-cell RNA sequencing
- Flow cytometry
Main finding
As reported in the abstract
Percentage of FGFR1-positive CD4+ T cells in peripheral blood
- FGFR1-positive CD4+ T cells also present in the synovium of active RA patients
- Single-cell RNA sequencing (scRNA-seq): peripheral Th (Tph) cells preferentially expressed FGFR1
- FGFR1-positive Tph cells displayed a terminal effector cell phenotype
- FGFR1-positive CD4+ T cells in peripheral blood expressed IL-21 and IFN-γ
- RA vs Healthy controls: P = 0.0035
Original publication
Fibroblast growth factor receptor 1 as a potential marker of terminal effector peripheral T helper cells in rheumatoid arthritis patients. Rheumatology (Oxford). Published 15 May 2023. doi:10.
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