Identification of Cell‐Specific Differential DNA Methylation Associated With Methotrexate Treatment Response in Rheumatoid Arthritis
Authors' conclusion
We identified cell-specific changes in DNAm that were associated with MTX treatment response in RA patients.
Study context
- Population
- Rheumatoid arthritis (RA) patients meeting ACR classification criteria, before and after initiation of methotrexate (MTX), from the Rheumatoid Arthritis Medication Study and the UCSF RA studytwo cohorts (n = 66 · Rheumatoid Arthritis Medication Study 66 · UCSF RA study 11
- Comparison
- MTX responders vs nonresponders
- Outcome
- Cell-specific differential DNA methylation associated with MTX response (EULAR response, DAS28-CRP)
- Follow-up
- 3-6 months
Methodological detailslongitudinal (before and after MTX initiation), two cohorts
- Longitudinal (before and after MTX initiation)
- Two cohorts
Main finding
As reported in the abstract
Cell-specific differential DNA methylation by MTX response
Differentially methylated positions associated with differential DNA methylation (DNAm) between responders and nonresponders at baseline in CD4+ T cells, CD8+ T cells and NK cells, after correction for multiple testing
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Cell-specific differentially methylated regions associated with MTX response
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Original publication
Identification of Cell‐Specific Differential DNA Methylation Associated With Methotrexate Treatment Response in Rheumatoid Arthritis. Arthritis Rheumatol. Published 9 May 2023. doi:10.
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