Autoinflammatory & rare systemic diseases
Factors related to elevated serum immunoglobulin G4 (IgG4) levels in a Japanese general population
Authors' conclusion
Elevated serum IgG4 levels in a Japanese general population were significantly associated with older age, male gender, and dietary intake of nutrients, with some of these factors identical to the epidemiological features of IgG4-RD.
Study context
- Population
- Residents of Ishikawa prefecture, Japan, undergoing general medical examinations
- Participants
- 1,201 residents
- Outcome
- Frequency of elevated serum IgG4 levels and associated factors
Methodological detailsgeneral population, logistic regression analysis
- General population
- Logistic regression analysis
Main finding
As reported in the abstract
Serum IgG4
Mean serum IgG4 concentration
44 mg/dL
Participants with elevated serum IgG4
42
3.5%
Observational data: associations, not effects.
Further findings
Factors associated with elevated serum IgG4 in men (subgroup)
- Older age, lower eGFR based on serum cystatin C and higher hemoglobin A1c (HbA1c) associated with elevated serum IgG4
Factors associated with elevated serum IgG4 in women (subgroup)
- Lower intake of lipids and fatty acids and higher intake of carbohydrates significantly associated with elevated serum IgG4
Secondary examinations in participants with elevated serum IgG4
- Diagnosed with possible IgG4-related retroperitoneal fibrosis, of 15 examined
- 1
Original publication
Factors related to elevated serum immunoglobulin G4 (IgG4) levels in a Japanese general population. Arthritis Res Ther. Published 6 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →